Requirements: English
Company: Iginnovate
Region: palinges , Vaud
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Job Title: Investigator - Cell Sciences Team
Posting Start Date: 5/6/25
Job Description:
The successful candidate will join an innovative Antibody Discovery and Engineering Department, with a strong record of success in developing novel antibody therapeutics in the field of immuno-oncology. The successful candidate will support mammalian antibody expression platforms and cell-line engineering to facilitate discovery activities . We are looking for a motivated and talented scientist with a deep understanding and hands-on experience in molecular biology, cell line engineering as well as antibody expression and purification to advance the next wave of novel therapeutic concepts.
SPECIFIC RESPONSIBILITIES:
- Transient protein expression/production- Antibodies (mg to gram-scale) and antigens- in different host cell lines (CHO, HEK) in flasks to support candidate selection
- Design and cloning of DNA constructs, perform DNA preparations
- Participate in stable pool generation to produce candidates to enable in vitro, in vivo and non-human primate studies. Perform production in bioreactors.
- Perform FACS staining for antigen detection, cancer cell line characterization
- Data analysis
- Purification of antigens and antibodies (Ni-NTA, Protein A, CEX) and characterization using different analytical methods (e.g., SDS-PAGE, SE-HPLC, IEF)
- Management of media stocks for all Antibody Discovery and Engineering department Present and discuss data in English in both informal and formal settings
- Maintain detailed and organized documentation
- Participate in day-to-day laboratory management
- Perform other relevant duties as required
- Collaborate across the matrix to support portfolio development
- Comply with HSE guidelines
EDUCATION AND DESIRED EXPERIENCE
- BSc/MSc in Biotechnology, Biochemistry or related discipline (e.g. cell biology/engineering) with demonstrated analytical skills is required
- Experience in the following: molecular biology, antibody or protein expression and characterization desired
- Experience in stable CHO pool development based on transposons is preferred
- Strong expertise in mammalian cell culture (small to large scale) and transfection methods is desired
- Strong experience with PCR, mutagenesis, DNA handling software, and bioinformatics tools
- Knowledge of antibody analytical methods is a plus
- Excellent time management and organizational skills
- Demonstrated ability to work in a multidisciplinary biologics discovery team
- Ability to manage multiple priorities and align with internal and external stakeholders around these priorities
- Excellent written and oral communication skills are necessary
- Professional level in English, both written and verbal.
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