Requirements: English
Company: Novartis Farmacutica
Region: Basel-Stadt , Basel-City
Senior Expert Data Science (Make-on-Demand Cheminformatics & AI)
Job ID REQ-10048606
Apr 22, 2025
Summary
The mission of Novartis is to reimagine medicine, and our team exemplifies that mission by consistently pushing the boundaries of drug discovery technology and data science. We interface with biologists, geneticists, chemists, and computational experts daily to execute complex collaborations and bring first-in-class and best-in-class drugs to patients with urgent unmet needs. We thrive in the earliest phases of drug discovery, partnering with diverse disease areas to nominate the next generation of drug targets and modalities, as well as elucidate complex biological mechanisms and sites of action.
To extend our impact, were seeking a creative, passionate, and tenacious scientist to join the data science team in Discovery Sciences (DSc) at Novartis Biomedical Research (BR). If you want to make a difference in early drug discovery and join our dynamic and collaborative team, we encourage you to apply today.
About the Role
Major accountabilities:
- Champion Make-on-Demand (MoD) workflows and develop computational strategies to accelerate hit finding activities.
- Develop synthon-based search strategies to leverage virtual chemical spaces efficiently.
- Contribute to the design of internal Low Molecular Weight (LMW) and DNA Encoded libraries to harness MoD potential during hit finding.
- Utilize expertise in cheminformatics, computational chemistry, and data science to generate and navigate virtual chemical spaces, build predictive models, and collaborate with project teams to accelerate early drug discovery.
- Possess a PhD in cheminformatics, computational chemistry, physics, or a related field, or equivalent experience in applying computational tools in life science/drug discovery.
- Hands-on experience with cheminformatics workflows, descriptors, and machine learning in cheminformatics contexts.
- Excellent scientific communication skills, including presenting complex data science concepts clearly and leveraging data visualization.
- Ability to work within interdisciplinary teams, demonstrating proactive communication and professionalism, fostering mutual respect and positivity.
- Experience working in Linux high-performance computing and cloud environments.
- Proficiency in Python scientific stacks, with knowledge of best practices in reproducible research.
Nice to have :
- Knowledge of structure-based and ligand-based approaches.
- Experience with ligand-protein docking, generative chemistry, deep learning, ligand-protein cofolding.
- Familiarity with Large Language Models (LLMs).
- Experience with organic synthesis and library design of small molecules.
- Experience using synthons and transformations for virtual space interrogation.
Novartis is committed to building an inclusive, diverse work environment.
Why Novartis: Join us to help create breakthroughs that change patients lives. Learn more at our culture and strategy.
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