Requirements: English
Company: WhatJobs
Region: Basel , Basel City
Senior Principal Scientist siRNA Chemistry
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Senior Principal Scientist siRNA Chemistry
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Summary
Job Description Summary
Location: Basel, Switzerland
Full time, onsite,
6000! Thats the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
At Novartis we are reimagining medicine to improve and extend people''s lives. We use innovative science and technology to address some of society''s most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. How can we continue to advance our science to help patients in need? We believe the answers are found when curious, courageous, and collaborative people are empowered to ask new questions, make bolder decisions, and take smarter risks.
Global Discovery Chemistry is seeking a passionate, creative PhD level medicinal chemist to complement our nucleotide and siRNA chemistry team in Basel. You will work highly collaboratively in a multidisciplinary environment at the interface between research and development to discover and develop novel siRNA therapies for high unmet medical needs.
Please note that we have the option to hire someone at a Principal Scientist level if this role level is a better match to the experience and skill set of the applicant.
About The Role
Your responsibilities will include, but are not limited to:
- Work highly collaboratively in a multidisciplinary project team to discover and develop novel oligonucleotide therapies across various disease areas.
- Lead a team of scientists dedicated to design and synthesize new nucleotide building blocks, linkers, backbones from small to medium scale
- Intellectually contribute to and own the success of assigned projects. Together with project teams, contribute experimentally and intellectually to conceive, implement and explore innovative siRNA chemistries to address key scientific questions and ensure their smooth transition to development
- Lead siRNA drug discovery projects in partnership with leaders from other functions
- Review and critically analyse data from projects using state-of-the-art data analysis and digital tools, to identify complex problems, develop scientific hypotheses, and design molecules.
- Drive innovation for the establishment of new projects, including the development of exploratory projects portfolio, innovative drug discovery solutions, and evaluation of new technologies in the RNA therapeutics space. This also involves collaborating with internal and external partners around the world to progress our projects.
- Document and communicate results and scientific findings to internal and external audiences, in patent filings or scientific publications as appropriate
- Support and develop team members by sharing your know-how and hands-on experience across your work environment
- Provide mentoring to scientists and lead through coaching and development of scientists, independent of reporting line and/or group affiliation, to increase their impact on projects.
What You Will Bring To The Role
- A PhD degree with a focus on synthesis and design of oligonucleotides.
- Demonstrated practical knowledge in medicinal chemistry with focus on oligo/nucleotides for 8+ years with a track record of deliverables. Experience in solid phase oligonucleotide synthesis is considered a plus
- A track record of people leadership and development skills
- A mind-set of curiosity and openness to diverse thinking, with an enthusiasm to develop yourself and others
- Innovative and independent problem-solving skills
- Interest in disruptive technologies and science trends, such as data science and automation/miniaturization, and their application to drug discovery
- Aptitude to work in a fast-paced team-oriented matrix environment Excellent written and verbal communication and strong influencing skills, with an ability to present and discuss project strategies and challenges
Why Novartis: Our purpose is to reimagine medicine to improve and extend peoples lives and our vision is to become the most valued and trusted medicines compan